Design and evaluation of the MOSFET type glucose biosensing system

A health monitoring system (HMS) involving a blood extraction device with a new type of hybrid biosensor comprising an enzyme and a semiconductor has recently been developed. A MOSFET was used as the transducer. The gate electrode was extracted from the MOSFET using a cable. Gold (Au)-plate-immobilized glucose oxidase (Go) was used as a biosensor and attached to the gate electrode. Go was immobilized on a self-assembled spacer combined with an Au electrode by the crosslink method using BSA as an additional bonding material. The electrode could be used to detect electrons generated by the oxidization of hydrogen peroxide produced by the reaction between Go and glucose using the constant electric current measurement system of the MOSFET-type hybrid biosensor. The sensitivities for the diluted whole blood and blood plasma were 61.4 and 171.2 V/(mol/L), respectively. The hybrid biosensor was useful for HMS. Copyright © 2013 VBRI press.